Publications

all Publications


Becuwe, M., Bond, L.M., Pinto, A.F.M., Boland, S., Mejhert, N., Elliott, S.D., Cicconet, M., Graham, M.M., Liu, X.N., Ilkayeva, O., Saghatelian, A., Walther, T.C., Farese, R.V. FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis. (2020) Journal of Cell Biology. 219(10). DOI: 10.1083/jcb.202006111

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Saghatelian, A. Networking in Circulation: Lipoproteins, PM20D1, and N-acyl Amino Acid Bioactivity. (2020) Cell Chemical Biology. 27(9):1112-1113. DOI: 10.1016/j.chembiol.2020.08.019

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Muthusamy, T., Cordes, T., Handzlik, M.K., You, L., Lim, E.W., Gengatharan, J., Pinto, A.F.M., Badur, M.G., Kolar, M.J., Wallace, M., Saghatelian, A., Metallo, C.M. Serine restriction alters sphingolipid diversity to constrain tumour growth. (2020) Nature. DOI: 10.1038/s41586-020-2609-x

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Chen, P.B., Black, A.S., Sobel, A.L., Zhao, Y., Mukherjee, P., Molparia, B., Moore, N.E., Aleman Muench, G.R., Wu, J., Chen, W., Pinto, A.F.M., Maryanoff, B.E., Saghatelian, A., Soroosh, P., Torkamani, A., Leman, L.J., Ghadiri, M.R. Directed remodeling of the mouse gut microbiome inhibits the development of atherosclerosis. (2020) Nature Biotechnology. DOI: 10.1038/s41587-020-0549-5

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Charron, M.J., Williams, L., Seki, Y., Du, X.Q., Chaurasia, B., Saghatelian, A., Summers, S.A., Katz, E.B., Vuguin, P.M., Reznik, S.E. Antioxidant Effects of N-Acetylcysteine Prevent Programmed Metabolic Disease in Mice. (2020) Diabetes. DOI: 10.2337/db19-1129

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Martinez, T.F., Vaughan, J., Saghatelian, A. Insights into GLP-1 Receptor Activation with a Nonpeptide Agonist. (2020) Biochemistry. DOI: 10.1021/acs.biochem.0c00180


Erikci Ertunc, M., Kok, B.P., Parsons, W.H., Wang, J.G., Tan, D., Donaldson, C.J., Pinto, A.F.M., Vaughan, J.M., Ngo, N., Lum, K.M., Henry, C.L., Coppola, A.R., Niphakis, M.J., Cravatt, B.F., Saez, E., Saghatelian, A. AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice. (2020) Journal of Biological Chemistry. DOI: 10.1074/jbc.RA119.012145

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Chen, D., Chao, D.L., Rocha, L., Kolar, M., Nguyen Huu, V.A., Krawczyk, M., Dasyani, M., Wang, T., Jafari, M., Jabari, M., Ross, K.D., Saghatelian, A., Hamilton, B.A., Zhang, K., Skowronska-Krawczyk, D. The lipid elongation enzyme ELOVL2 is a molecular regulator of aging in the retina. (2020) Aging Cell.:e13100 DOI: 10.1111/acel.13100

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Martinez, T.F., Chu, Q., Donaldson, C., Tan, D., Shokhirev, M.N., Saghatelian, A. Accurate annotation of human protein-coding small open reading frames. (2019) Nature Chemical Biology.:458-468 DOI: 10.1038/s41589-019-0425-0

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Chu, Q., Martinez, T.F., Novak, S.W., Donaldson, C.J., Tan, D., Vaughan, J.M., Chang, T., Diedrich, J.K., Andrade, L., Kim, A., Zhang, T., Manor, U., Saghatelian, A. Regulation of the ER stress response by a mitochondrial microprotein. (2019) Nature Communications. 10(1):4883. DOI: 10.1038/s41467-019-12816-z

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Wang, H., Kolar, M.J., Chang, T., Rizo, J., Konduri, S., McNerlin, C., Saghatelian, A., Siegel, D. Stereochemistry of Linoleic Acid Esters of Hydroxy Linoleic Acids. (2019) Organic Letters. 21(19):8080-8084. DOI: 10.1021/acs.orglett.9b03054

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Syed, I., Rubinde Celis, M.F., Mohan, J.F., Moraes-Vieira, P.M., Vijayakumar, A., Nelson, A.T., Siegel, D., Saghatelian, A., Mathis, D., Kahn, B.B. PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice. (2019) Journal of Clinical Investigation. 129. DOI: 10.1172/JCI122445

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Chu, Q., Chang, T., Saghatelian, A. Substrate-Selective Enzyme Inhibitors. (2019) Trends in Pharmacological Sciences. DOI: 10.1016/j.tips.2019.07.009

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Zhou, P., Santoro, A., Peroni, O.D., Nelson, A.T., Saghatelian, A., Siegel, D., Kahn, B.B. PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms. (2019) Journal of Clinical Investigation. 129(10):4138-4150. DOI: 10.1172/JCI127092

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Tan, D., Ertunc, M.E., Konduri, S., Zhang, J., Pinto, A.M., Chu, Q., Kahn, B.B., Siegel, D., Saghatelian, A. Discovery of FAHFA-containing Triacylglycerols and Their Metabolic Regulation. (2019) Journal of the American Chemical Society. 141(22):8798-8806. DOI: 10.1021/jacs.9b00045

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Kolar, M.J., Konduri, S., Chang, T., Wang, H., McNerlin, C., Ohlsson, L., Härröd, M., Siegel, D., Saghatelian, A. Linoleic acid esters of hydroxy linoleic acids are anti-inflammatory lipids found in plants and mammals. (2019) J. Biol. Chem. DOI: 10.1074/jbc.RA118.006956

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Wang, H., Chang, T., Konduri, S., Huang, J., Saghatelian, A., Siegel, D. Synthesis of chemically edited derivatives of the endogenous regulator of inflammation 9-PAHSA. (2019) Journal of Antibiotics. DOI: 10.1038/s41429-019-0180-1

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Chu, Q., Saghatelian, A. A Hidden ORF Reveals an Immune Protector. (2019) Biochemistry. DOI: 10.1021/acs.biochem.8b01317


Choi, S.H., Martinez, T.F., Kim, S., Donaldson, C., Shokhirev, M.N., Saghatelian, A., Jones, K.A. CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability. (2019) Genes & Development. 33(7-8):418-435. DOI: 10.1101/gad.322339.118

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Garcia, D., Hellberg, K., Chaix, A., Wallace, M., Herzig, S., Badur, M.G., Lin, T., Shokhirev, M.N., Pinto, A.F.M., Ross, D.S., Saghatelian, A., Panda, S., Dow, L.E., Metallo, C.M., Shaw, R.J. Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD. (2019) Cell Reports. 26(1):192-208.e6. DOI: 10.1016/j.celrep.2018.12.036

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Rathore, A., Martinez, T.F., Chu, Q., Saghatelian, A. Small, but mighty? Searching for human microproteins and their potential for understanding health and disease. (2018) Expert Review of Proteomics. 15(12):963-965. DOI: 10.1080/14789450.2018.1547194


Rathore, A., Chu, Q., Tan, D., Martinez, T.F., Donaldson, C.J., Diedrich, J.K., Yates, J.R., Saghatelian, A. MIEF1 Microprotein Regulates Mitochondrial Translation. (2018) Biochemistry. DOI: 10.1021/acs.biochem.8b00726

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Syed, I., Lee, J., Peroni, O.D., Yore, M.M., Moraes-Vieira, P.M., Santoro, A., Wellenstein, K., Smith, U., McGraw, T.E., Saghatelian, A., Kahn, B.B. Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects. (2018) Cell Metabolism. DOI: 10.1016/j.cmet.2018.09.007

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Zarrinpar, A., Chaix, A., Xu, Z.Z., Chang, M.W., Marotz, C.A., Saghatelian, A., Knight, R., Panda, S. Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism. (2018) Nature Communications. 9(1):2872. DOI: 10.1038/s41467-018-05336-9

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Kolar, M.J., Nelson, A.T., Chang, T., Ertunc, M.E., Christy, M.P., Ohlsson, L., Härröd, M., Kahn, B.B., Siegel, D., Saghatelian, A. Faster Protocol for Endogenous Fatty Acid Esters of Hydroxy Fatty Acid (FAHFA) Measurements. (2018) Analytical Chemistry. 90(8):5358-5365. DOI: 10.1021/acs.analchem.8b00503

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Ma, J., Saghatelian, A., Shokhirev, M.N. The influence of transcript assembly on the proteogenomics discovery of microproteins. (2018) PLOS One. 13(3):e0194518. DOI: 10.1371/journal.pone.0194518

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Sanz Muñoz, S., Li, H., Ruberu, K., Chu, Q., Saghatelian, A., Ooi, L., Garner, B. The serine protease HtrA1 contributes to the formation of an extracellular 25-kDa apolipoprotein E fragment that stimulates neuritogenesis. (2018) Journal of Biological Chemistry. DOI: 10.1074/jbc.RA117.001278

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Syed, I., Lee, J., Moraes-Vieira, P.M., Donaldson, C.J., Sontheimer, A., Aryal, P., Wellenstein, K., Kolar, M.J., Nelson, A.T., Siegel, D., Mokrosinski, J., Farooqi, I.S., Zhao, J.J., Yore, M.M., Peroni, O.D., Saghatelian, A., Kahn, B.B. Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis. (2018) Cell Metabolism. 27(2):419-427.e4. DOI: 10.1016/j.cmet.2018.01.001

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Aebersold, R., Agar, J.N., Amster, I.J., Baker, M.S., Bertozzi, C.R., Boja, E.S., Costello, C.E., Cravatt, B.F., Fenselau, C., Garcia, B.A., Ge, Y., Gunawardena, J., Hendrickson, R.C., Hergenrother, P.J., Huber, C.G., Ivanov, A.R., Jensen, O.N., Jewett, M.C., Kelleher, N.L., Kiessling, L.L., Krogan, N.J., Larsen, M.R., Loo, J.A., Ogorzalek Loo, R.R., Lundberg, E., MacCoss, M.J., Mallick, P., Mootha, V.K., Mrksich, M., Muir, T.W., Patrie, S.M., Pesavento, J.J., Pitteri, S.J., Rodriguez, H., Saghatelian, A., Sandoval, W., Schlüter, H., Sechi, S., Slavoff, S.A., Smith, L.M., Snyder, M.P., Thomas, P.M., Uhlén, M., Van Eyk, J.E., Vidal, M., Walt, D.R., White, F.M., Williams, E.R., Wohlschlager, T., Wysocki, V.H., Yates, N.A., Young, N.L., Zhang, B. How many human proteoforms are there? (2018) Nature Chemical Biology. 14(3):206-214. DOI: 10.1038/nchembio.2576

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Sulli, G., Rommel, A., Wang, X., Kolar, M.J., Puca, F., Saghatelian, A., Plikus, M.V., Verma, I.M., Panda, S. Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence. (2018) Nature. 553(7688):351-355. DOI: 10.1038/nature25170

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Mesci, P., Macia, A., Moore, S.M., Shiryaev, S.A., Pinto, A., Huang, C.T., Tejwani, L., Fernandes, I.R., Suarez, N.A., Kolar, M.J., Montefusco, S., Rosenberg, S.C., Herai, R.H., Cugola, F.R., Russo, F.B., Sheets, N., Saghatelian, A., Shresta, S., Momper, J.D., Siqueira-Neto, J.L., Corbett, K.D., Beltrão-Braga, P.C.B., Terskikh, A.V., Muotri, A.R. Blocking Zika virus vertical transmission. (2018) Scientific Reports. 8(1):1218. DOI: 10.1038/s41598-018-19526-4

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Saison-Ridinger, M., DelGiorno, K.E., Zhang, T., Kraus, A., French, R., Jaquish, D., Tsui, C., Erikson, G., Spike, B.T., Shokhirev, M.N., Liddle, C., Yu, R.T., Downes, M., Evans, R.M., Saghatelian, A., Lowy, A.M., Wahl, G.M. Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy. (2017) PLOS One. 12(12):e0189051. DOI: 10.1371/journal.pone.0189051

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Saghatelian, A. Novel Biology and Druggable Targets via Chemoproteomics. (2017) Biochemistry. DOI: 10.1021/acs.biochem.7b01167


Vijayakumar, A., Aryal, P., Wen, J., Syed, I., Vazirani, R.P., Moraes-Vieira, P.M., Camporez, J.P., Gallop, M.R., Perry, R.J., Peroni, O.D., Shulman, G.I., Saghatelian, A., McGraw, T.E., Kahn, B.B. Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport. (2017) Cell Reports. 21(4):1021-1035. DOI: 10.1016/j.celrep.2017.09.091

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Arnoult, N., Correia, A., Ma, J., Merlo, A., Garcia-Gomez, S., Maric, M., Tognetti, M., Benner, C.W., Boulton, S.J., Saghatelian, A., Karlseder, J. Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN. (2017) Nature. 549(7673):548-552. DOI: 10.1038/nature24023

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Chu, Q., Rathore, A., Diedrich, J.K., Donaldson, C.J., Yates, J.R., Saghatelian, A. Identification of Microprotein-Protein Interactions via APEX Tagging. (2017) Biochemistry. 56(26):3299-3306. DOI: 10.1021/acs.biochem.7b00265

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Nelson, A.T., Kolar, M.J., Chu, Q., Syed, I., Kahn, B.B., Saghatelian, A., Siegel, D. Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation. (2017) Journal of the American Chemical Society. 139(13):4943-4947. DOI: 10.1021/jacs.7b01269

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Krzeszinski, J.Y., Schwaid, A.G., Cheng, W.Y., Jin, Z., Gallegos, Z.R., Saghatelian, A., Wan, Y. Lipid Osteoclastokines Regulate Breast Cancer Bone Metastasis. (2017) Endocrinology. 158(3):477-489. DOI: 10.1210/en.2016-1570

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Grünberg, J.R., Hoffmann, J.M., Hedjazifar, S., Nerstedt, A., Jenndahl, L., Elvin, J., Castellot, J., Wei, L., Movérare-Skrtic, S., Ohlsson, C., Holm, L.M., Bäckhed, F., Syed, I., Bosch, F., Saghatelian, A., Kahn, B.B., Hammarstedt, A., Smith, U. Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance. (2017) Scientific Reports. 7:43515. DOI: 10.1038/srep43515

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Howell, J.J., Hellberg, K., Turner, M., Talbott, G., Kolar, M.J., Ross, D.S., Hoxhaj, G., Saghatelian, A., Shaw, R.J., Manning, B.D. Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex. (2017) Cell Metabolism. 25(2):463-471. DOI: 10.1016/j.cmet.2016.12.009

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Oishi, Y., Spann, N.J., Link, V.M., Muse, E.D., Strid, T., Edillor, C., Kolar, M.J., Matsuzaka, T., Hayakawa, S., Tao, J., Kaikkonen, M.U., Carlin, A.F., Lam, M.T., Manabe, I., Shimano, H., Saghatelian, A., Glass, C.K. SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism. (2017) Cell Metabolism. 25(2):412-427. DOI: 10.1016/j.cmet.2016.11.009

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D’Lima, N.G., Ma, J., Winkler, L., Chu, Q., Loh, K.H., Corpuz, E.O., Budnik, B.A., Lykke-Andersen, J., Saghatelian, A., Slavoff, S.A. A human microprotein that interacts with the mRNA decapping complex. (2017) Nature Chemical Biology. 13(2):174-180. DOI: 10.1038/nchembio.2249

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Chen, P., Zuo, H., Xiong, H., Kolar, M.J., Chu, Q., Saghatelian, A., Siegwart, D.J., Wan, Y. Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis. (2017) Proceedings of the National Academy of Sciences of the United States of America. 114(3):580-585. DOI: 10.1073/pnas.1614035114

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Matsumoto, A., Pasut, A., Matsumoto, M., Yamashita, R., Fung, J., Monteleone, E., Saghatelian, A., Nakayama, K.I., Clohessy, J.G., Pandolfi, P.P. mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide. (2017) Nature. 541(7636):228-232. DOI: 10.1038/nature21034

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Saghatelian, A., Cravatt, B. Glucagon and Thyroid Hormone: A Championship Team. (2016) Cell. 167(3):604-605. DOI: 10.1016/j.cell.2016.10.008

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Svensson, R.U., Parker, S.J., Eichner, L.J., Kolar, M.J., Wallace, M., Brun, S.N., Lombardo, P.S., Van Nostrand, J.L., Hutchins, A., Vera, L., Gerken, L., Greenwood, J., Bhat, S., Harriman, G., Westlin, W.F., Harwood, H.J., Saghatelian, A., Kapeller, R., Metallo, C.M., Shaw, R.J. Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models. (2016) Nature Medicine. 22(10):1108-1119. DOI: 10.1038/nm.4181

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Lee, J., Moraes-Vieira, P.M., Castoldi, A., Aryal, P., Yee, E.U., Vickers, C., Parnas, O., Donaldson, C.J., Saghatelian, A., Kahn, B.B. Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses. (2016) Journal of Biological Chemistry. 291(42):22207-22217. DOI: 10.1074/jbc.M115.703835

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Pirhaji, L., Milani, P., Leidl, M., Curran, T., Avila-Pacheco, J., Clish, C.B., White, F.M., Saghatelian, A., Fraenkel, E. Revealing disease-associated pathways by network integration of untargeted metabolomics. (2016) Nature Methods. 13(9):770-6. DOI: 10.1038/nmeth.3940

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Kolar, M.J., Kamat, S.S., Parsons, W.H., Homan, E.A., Maher, T., Peroni, O.D., Syed, I., Fjeld, K., Molven, A., Kahn, B.B., Cravatt, B.F., Saghatelian, A. Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase. (2016) Biochemistry. 55(33):4636-41. DOI: 10.1021/acs.biochem.6b00565

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Chu, Q., Diedrich, J.K., Vaughan, J.M., Donaldson, C.J., Nunn, M.F., Lee, K.F., Saghatelian, A. HtrA1 Proteolysis of ApoE In Vitro Is Allele Selective. (2016) Journal of the American Chemical Society. 138(30):9473-8. DOI: 10.1021/jacs.6b03463

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Moraes-Vieira, P.M., Saghatelian, A., Kahn, B.B. GLUT4 Expression in Adipocytes Regulates De Novo Lipogenesis and Levels of a Novel Class of Lipids With Antidiabetic and Anti-inflammatory Effects. (2016) Diabetes. 65(7):1808-15. DOI: 10.2337/db16-0221

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Parsons, W.H., Kolar, M.J., Kamat, S.S., Cognetta, A.B., Hulce, J.J., Saez, E., Kahn, B.B., Saghatelian, A., Cravatt, B.F. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs. (2016) Nature Chemical Biology. 12(5):367-372. DOI: 10.1038/nchembio.2051

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Ma, J., Diedrich, J.K., Jungreis, I., Donaldson, C., Vaughan, J., Kellis, M., Yates, J.R., Saghatelian, A. Improved Identification and Analysis of Small Open Reading Frame Encoded Polypeptides. (2016) Analytical Chemistry. 88(7):3967-75. DOI: 10.1021/acs.analchem.6b00191

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Zhang, T., Chen, S., Syed, I., Ståhlman, M., Kolar, M.J., Homan, E.A., Chu, Q., Smith, U., Borén, J., Kahn, B.B., Saghatelian, A. A LC-MS-based workflow for measurement of branched fatty acid esters of hydroxy fatty acids. (2016) Nature Protocols. 11(4):747-63. DOI: 10.1038/nprot.2016.040

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Wei, W., Schwaid, A.G., Wang, X., Wang, X., Chen, S., Chu, Q., Saghatelian, A., Wan, Y. Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects. (2016) Cell Metabolism. 23(3):479-91. DOI: 10.1016/j.cmet.2015.12.010

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Saghatelian, A., Nomura, D.K., Weerapana, E. Editorial overview: Omics: The maturation of chemical biology. (2016) Current Opinion in Chemical Biology. 30:v-vi. DOI: 10.1016/j.cbpa.2015.12.005


Saghatelian, A., Couso, J.P. Discovery and characterization of smORF-encoded bioactive polypeptides. (2015) Nature Chemical Biology. 11(12):909-16. DOI: 10.1038/nchembio.1964

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Denli, A.M., Narvaiza, I., Kerman, B.E., Pena, M., Benner, C., Marchetto, M.C., Diedrich, J.K., Aslanian, A., Ma, J., Moresco, J.J., Moore, L., Hunter, T., Saghatelian, A., Gage, F.H. Primate-specific ORF0 contributes to retrotransposon-mediated diversity. (2015) Cell. 163(3):583-93. DOI: 10.1016/j.cell.2015.09.025

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Zhang, T., Barclay, L., Walensky, L.D., Saghatelian, A. Regulation of mitochondrial ceramide distribution by members of the BCL-2 family. (2015) Journal of Lipid Research. 56(8):1501-10. DOI: 10.1194/jlr.M058750

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Zhang, T., Walensky, L.D., Saghatelian, A. A nonapoptotic role for BAX and BAK in eicosanoid metabolism. (2015) ACS Chemical Biology. 10(6):1398-403. DOI: 10.1021/acschembio.5b00168

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Zamboni, N., Saghatelian, A., Patti, G.J. Defining the metabolome: size, flux, and regulation. (2015) Molecular Cell. 58(4):699-706. DOI: 10.1016/j.molcel.2015.04.021

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Wu, J., Okamura, D., Li, M., Suzuki, K., Luo, C., Ma, L., He, Y., Li, Z., Benner, C., Tamura, I., Krause, M.N., Nery, J.R., Du, T., Zhang, Z., Hishida, T., Takahashi, Y., Aizawa, E., Kim, N.Y., Lajara, J., Guillen, P., Campistol, J.M., Esteban, C.R., Ross, P.J., Saghatelian, A., Ren, B., Ecker, J.R., Izpisua Belmonte, J.C. An alternative pluripotent state confers interspecies chimaeric competency. (2015) Nature. 521(7552):316-21. DOI: 10.1038/nature14413

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Kim, K.J., Kim, Y.W., Kim, Y.G., Park, H.M., Jin, J.M., Hwan Kim, Y., Yang, Y.H., Kyu Lee, J., Chung, J., Lee, S.G., Saghatelian, A. Stable isotopic labeling-based quantitative targeted glycomics (i-QTaG). (2015) Biotechnol. Prog. 31(3):840-8. DOI: 10.1002/btpr.2078

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Jin, Z., Du, Y., Schwaid, A.G., Asterholm, I.W., Scherer, P.E., Saghatelian, A., Wan, Y. Maternal adiponectin controls milk composition to prevent neonatal inflammation. (2015) Endocrinology. 156(4):1504-13. DOI: 10.1210/en.2014-1738

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Chu, Q., Ma, J., Saghatelian, A. Identification and characterization of sORF-encoded polypeptides. (2015) Critical Reviews in Biochemistry and Molecular Biology. 50(2):134-41. DOI: 10.3109/10409238.2015.1016215

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Prothiwa, M., Syed, I., Huising, M.O., van der Meulen, T., Donaldson, C.J., Trauger, S.A., Kahn, B.B., Saghatelian, A. Data-driven synthesis of proteolysis-resistant peptide hormones. (2014) Journal of the American Chemical Society. 136(51):17710-3. DOI: 10.1021/ja5065735

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Nazarian, A., Lawlor, K., Yi, S.S., Philip, J., Ghosh, M., Yaneva, M., Villanueva, J., Saghatelian, A., Assel, M., Vickers, A.J., Eastham, J.A., Scher, H.I., Carver, B.S., Lilja, H., Tempst, P. Inhibition of circulating dipeptidyl peptidase 4 activity in patients with metastatic prostate cancer. (2014) Mol. Cell Proteomics. 13(11):3082-96. DOI: 10.1074/mcp.M114.038836

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Yore, M.M., Syed, I., Moraes-Vieira, P.M., Zhang, T., Herman, M.A., Homan, E.A., Patel, R.T., Lee, J., Chen, S., Peroni, O.D., Dhaneshwar, A.S., Hammarstedt, A., Smith, U., McGraw, T.E., Saghatelian, A., Kahn, B.B. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. (2014) Cell. 159(2):318-32. DOI: 10.1016/j.cell.2014.09.035

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Oliver, P.M., Crooks, J.A., Leidl, M., Yoon, E.J., Saghatelian, A., Weibel, D.B. Localization of anionic phospholipids in Escherichia coli cells. (2014) J. Bacteriol. 196(19):3386-98. DOI: 10.1128/JB.01877-14

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Johnson, L.M., Barrick, S., Hager, M.V., McFedries, A., Homan, E.A., Rabaglia, M.E., Keller, M.P., Attie, A.D., Saghatelian, A., Bisello, A., Gellman, S.H. A potent α/β-peptide analogue of GLP-1 with prolonged action in vivo. (2014) Journal of the American Chemical Society. 136(37):12848-51. DOI: 10.1021/ja507168t

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Maianti, J.P., McFedries, A., Foda, Z.H., Kleiner, R.E., Du, X.Q., Leissring, M.A., Tang, W.J., Charron, M.J., Seeliger, M.A., Saghatelian, A., Liu, D.R. Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. (2014) Nature. 511(7507):94-8. DOI: 10.1038/nature13297

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Chin, R.M., Fu, X., Pai, M.Y., Vergnes, L., Hwang, H., Deng, G., Diep, S., Lomenick, B., Meli, V.S., Monsalve, G.C., Hu, E., Whelan, S.A., Wang, J.X., Jung, G., Solis, G.M., Fazlollahi, F., Kaweeteerawat, C., Quach, A., Nili, M., Krall, A.S., Godwin, H.A., Chang, H.R., Faull, K.F., Guo, F., Jiang, M., Trauger, S.A., Saghatelian, A., Braas, D., Christofk, H.R., Clarke, C.F., Teitell, M.A., Petrascheck, M., Reue, K., Jung, M.E., Frand, A.R., Huang, J. The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. (2014) Nature. 510(7505):397-401. DOI: 10.1038/nature13264

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Slavoff, S.A., Heo, J., Budnik, B.A., Hanakahi, L.A., Saghatelian, A. A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining. (2014) Journal of Biological Chemistry. 289(16):10950-7. DOI: 10.1074/jbc.C113.533968

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Ma, J., Ward, C.C., Jungreis, I., Slavoff, S.A., Schwaid, A.G., Neveu, J., Budnik, B.A., Kellis, M., Saghatelian, A. Discovery of human sORF-encoded polypeptides (SEPs) in cell lines and tissue. (2014) J. Proteome Res. 13(3):1757-65. DOI: 10.1021/pr401280w

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Lone, A.M., Leidl, M., McFedries, A.K., Horner, J.W., Creemers, J., Saghatelian, A. Deletion of PREPl causes growth impairment and hypotonia in mice. (2014) PLOS One. 9(2):e89160. DOI: 10.1371/journal.pone.0089160

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Pauli, A., Norris, M.L., Valen, E., Chew, G.L., Gagnon, J.A., Zimmerman, S., Mitchell, A., Ma, J., Dubrulle, J., Reyon, D., Tsai, S.Q., Joung, J.K., Saghatelian, A., Schier, A.F. Toddler: an embryonic signal that promotes cell movement via Apelin receptors. (2014) Science. 343(6172):1248636. DOI: 10.1126/science.1248636

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Schwaid, A.G., Shannon, D.A., Ma, J., Slavoff, S.A., Levin, J.Z., Weerapana, E., Saghatelian, A. Chemoproteomic discovery of cysteine-containing human short open reading frames. (2013) Journal of the American Chemical Society. 135(45):16750-3. DOI: 10.1021/ja406606j

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López-Sagaseta, J., Dulberger, C.L., McFedries, A., Cushman, M., Saghatelian, A., Adams, E.J. MAIT recognition of a stimulatory bacterial antigen bound to MR1. (2013) Journal of Immunology. 191(10):5268-77. DOI: 10.4049/jimmunol.1301958

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Liu, S., Brown, J.D., Stanya, K.J., Homan, E., Leidl, M., Inouye, K., Bhargava, P., Gangl, M.R., Dai, L., Hatano, B., Hotamisligil, G.S., Saghatelian, A., Plutzky, J., Lee, C.H. A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use. (2013) Nature. 502(7472):550-4. DOI: 10.1038/nature12710

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Zhang, T., Saghatelian, A. Emerging roles of lipids in BCL-2 family-regulated apoptosis. (2013) Biochimica et Biophysica Acta. 1831(10):1542-54. DOI: 10.1016/j.bbalip.2013.03.001

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Kim, Y.G., Lone, A.M., Saghatelian, A. Analysis of the proteolysis of bioactive peptides using a peptidomics approach. (2013) Nature Protocols. 8(9):1730-42. DOI: 10.1038/nprot.2013.104

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Tatematsu, S., Francis, S.A., Natarajan, P., Rader, D.J., Saghatelian, A., Brown, J.D., Michel, T., Plutzky, J. Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium. (2013) Arterioscler. Thromb. Vasc. Biol. 33(8):1788-94. DOI: 10.1161/ATVBAHA.113.301300

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Mitchell, A.J., Lone, A.M., Tinoco, A.D., Saghatelian, A. Proteolysis controls endogenous substance P levels. (2013) PLOS One. 8(7):e68638. DOI: 10.1371/journal.pone.0068638

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Miraldi, E.R., Sharfi, H., Friedline, R.H., Johnson, H., Zhang, T., Lau, K.S., Ko, H.J., Curran, T.G., Haigis, K.M., Yaffe, M.B., Bonneau, R., Lauffenburger, D.A., Kahn, B.B., Kim, J.K., Neel, B.G., Saghatelian, A., White, F.M. Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice. (2013) Integr Biol (Camb). 5(7):940-63. DOI: 10.1039/c3ib40013a

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McFedries, A., Schwaid, A., Saghatelian, A. Methods for the elucidation of protein-small molecule interactions. (2013) Chemistry & Biology. 20(5):667-73. DOI: 10.1016/j.chembiol.2013.04.008

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López-Sagaseta, J., Dulberger, C.L., Crooks, J.E., Parks, C.D., Luoma, A.M., McFedries, A., Van Rhijn, I., Saghatelian, A., Adams, E.J. The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins. (2013) Proceedings of the National Academy of Sciences of the United States of America. 110(19):E1771-8. DOI: 10.1073/pnas.1222678110

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Lone, A.M., Kim, Y.G., Saghatelian, A. Peptidomics methods for the identification of peptidase-substrate interactions. (2013) Current Opinion in Chemical Biology. 17(1):83-9. DOI: 10.1016/j.cbpa.2012.10.038

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Cezairliyan, B., Vinayavekhin, N., Grenfell-Lee, D., Yuen, G.J., Saghatelian, A., Ausubel, F.M. Identification of Pseudomonas aeruginosa phenazines that kill Caenorhabditis elegans. (2013) PLOS pathogens. 9(1):e1003101. DOI: 10.1371/journal.ppat.1003101

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Slavoff, S.A., Mitchell, A.J., Schwaid, A.G., Cabili, M.N., Ma, J., Levin, J.Z., Karger, A.D., Budnik, B.A., Rinn, J.L., Saghatelian, A. Peptidomic discovery of short open reading frame-encoded peptides in human cells. (2013) Nature Chemical Biology. 9(1):59-64. DOI: 10.1038/nchembio.1120

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Slavoff, S.A., Saghatelian, A. Discovering ligand-receptor interactions. (2012) Nature Biotechnology. 30(10):959-61. DOI: 10.1038/nbt.2373


Du, Y., Yang, M., Wei, W., Huynh, H.D., Herz, J., Saghatelian, A., Wan, Y. Macrophage VLDL receptor promotes PAFAH secretion in mother’s milk and suppresses systemic inflammation in nursing neonates. (2012) Nature Communications. 3:1008. DOI: 10.1038/ncomms2011

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Du, Y., Yang, M., Lee, S., Behrendt, C.L., Hooper, L.V., Saghatelian, A., Wan, Y. Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity. (2012) Genes & Development. 26(12):1306-11. DOI: 10.1101/gad.191031.112

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Kim, Y.G., Lone, A.M., Nolte, W.M., Saghatelian, A. Peptidomics approach to elucidate the proteolytic regulation of bioactive peptides. (2012) Proceedings of the National Academy of Sciences of the United States of America. 109(22):8523-7. DOI: 10.1073/pnas.1203195109

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Tinoco, A.D., Thomas, H.R., Incarvito, C.D., Saghatelian, A., Valentine, A.M. Cytotoxicity of a Ti(IV) compound is independent of serum proteins. (2012) Proceedings of the National Academy of Sciences of the United States of America. 109(13):5016-21. DOI: 10.1073/pnas.1119303109

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Guzman-Rojas, L., Rangel, R., Salameh, A., Edwards, J.K., Dondossola, E., Kim, Y.G., Saghatelian, A., Giordano, R.J., Kolonin, M.G., Staquicini, F.I., Koivunen, E., Sidman, R.L., Arap, W., Pasqualini, R. Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment. (2012) Proceedings of the National Academy of Sciences of the United States of America. 109(5):1637-42. DOI: 10.1073/pnas.1120790109

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Kim, Y.G., Saghatelian, A. Functional analysis of protein targets by metabolomic approaches. (2012) Top Curr Chem. 324:137-62. DOI: 10.1007/128_2011_284

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Vinayavekhin, N., Saghatelian, A. Discovery of a protein-metabolite interaction between unsaturated fatty acids and the nuclear receptor Nur77 using a metabolomics approach. (2011) Journal of the American Chemical Society. 133(43):17168-71. DOI: 10.1021/ja208199h

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Tinoco, A.D., Saghatelian, A. Investigating endogenous peptides and peptidases using peptidomics. (2011) Biochemistry. 50(35):7447-61. DOI: 10.1021/bi200417k

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Lone, A.M., Bachovchin, D.A., Westwood, D.B., Speers, A.E., Spicer, T.P., Fernandez-Vega, V., Chase, P., Hodder, P.S., Rosen, H., Cravatt, B.F., Saghatelian, A. A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors. (2011) Journal of the American Chemical Society. 133(30):11665-74. DOI: 10.1021/ja2036095

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Brown, J.D., Oligino, E., Rader, D.J., Saghatelian, A., Plutzky, J. VLDL hydrolysis by hepatic lipase regulates PPARδ transcriptional responses. (2011) PLOS One. 6(7):e21209. DOI: 10.1371/journal.pone.0021209

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Homan, E.A., Kim, Y.G., Cardia, J.P., Saghatelian, A. Monoalkylglycerol ether lipids promote adipogenesis. (2011) Journal of the American Chemical Society. 133(14):5178-81. DOI: 10.1021/ja111173c

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Kim, Y.G., Lou, A.C., Saghatelian, A. A metabolomics strategy for detecting protein-metabolite interactions to identify natural nuclear receptor ligands. (2011) Mol Biosyst. 7(4):1046-9. DOI: 10.1039/c0mb00324g

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Tinoco, A.D., Kim, Y.G., Tagore, D.M., Wiwczar, J., Lane, W.S., Danial, N.N., Saghatelian, A. A peptidomics strategy to elucidate the proteolytic pathways that inactivate peptide hormones. (2011) Biochemistry. 50(12):2213-22. DOI: 10.1021/bi2000033

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Scharf, L., Li, N.S., Hawk, A.J., Garzón, D., Zhang, T., Fox, L.M., Kazen, A.R., Shah, S., Haddadian, E.J., Gumperz, J.E., Saghatelian, A., Faraldo-Gómez, J.D., Meredith, S.C., Piccirilli, J.A., Adams, E.J. The 2.5 Å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation. (2010) Immunity. 33(6):853-62. DOI: 10.1016/j.immuni.2010.11.026

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Lone, A.M., Nolte, W.M., Tinoco, A.D., Saghatelian, A. Peptidomics of the prolyl peptidases. (2010) AAPS J. 12(4):483-91. DOI: 10.1208/s12248-010-9208-y

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Vinayavekhin, N., Saghatelian, A. Untargeted metabolomics. (2010) Current Protocols in Molecular Biology. Chapter 30:Unit 30.1.1-24. DOI: 10.1002/0471142727.mb3001s90

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Tinoco, A.D., Tagore, D.M., Saghatelian, A. Expanding the dipeptidyl peptidase 4-regulated peptidome via an optimized peptidomics platform. (2010) Journal of the American Chemical Society. 132(11):3819-30. DOI: 10.1021/ja909524e

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Vinayavekhin, N., Homan, E.A., Saghatelian, A. Exploring disease through metabolomics. (2010) ACS Chemical Biology. 5(1):91-103. DOI: 10.1021/cb900271r

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Nolte, W.M., Tagore, D.M., Lane, W.S., Saghatelian, A. Peptidomics of prolyl endopeptidase in the central nervous system. (2009) Biochemistry. 48(50):11971-81. DOI: 10.1021/bi901637c

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MacBeath, G., Saghatelian, A. The promise and challenge of ‘-omic’ approaches. (2009) Current Opinion in Chemical Biology. 13(5-6):501-2. DOI: 10.1016/j.cbpa.2009.10.008


Vinayavekhin, N., Saghatelian, A. Regulation of alkyl-dihydrothiazole-carboxylates (ATCs) by iron and the pyochelin gene cluster in Pseudomonas aeruginosa. (2009) ACS Chemical Biology. 4(8):617-23. DOI: 10.1021/cb900075n

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Rodgers, M.A., Saghatelian, A., Yang, P.L. Identification of an overabundant cholesterol precursor in hepatitis B virus replicating cells by untargeted lipid metabolite profiling. (2009) Journal of the American Chemical Society. 131(14):5030-1. DOI: 10.1021/ja809949r

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Tagore, D.M., Nolte, W.M., Neveu, J.M., Rangel, R., Guzman-Rojas, L., Pasqualini, R., Arap, W., Lane, W.S., Saghatelian, A. Peptidase substrates via global peptide profiling. (2009) Nature Chemical Biology. 5(1):23-5. DOI: 10.1038/nchembio.126

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Tagore, R., Thomas, H.R., Homan, E.A., Munawar, A., Saghatelian, A. A global metabolite profiling approach to identify protein-metabolite interactions. (2008) Journal of the American Chemical Society. 130(43):14111-3. DOI: 10.1021/ja806463c

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Voelcker, N.H., Guckian, K.M., Saghatelian, A., Ghadiri, M.R. Sequence-addressable DNA logic. (2008) Small. 4(4):427-31. DOI: 10.1002/smll.200700113


Chamero, P., Marton, T.F., Logan, D.W., Flanagan, K., Cruz, J.R., Saghatelian, A., Cravatt, B.F., Stowers, L. Identification of protein pheromones that promote aggressive behaviour. (2007) Nature. 450(7171):899-902. DOI: 10.1038/nature05997

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Everley, P.A., Gartner, C.A., Haas, W., Saghatelian, A., Elias, J.E., Cravatt, B.F., Zetter, B.R., Gygi, S.P. Assessing enzyme activities using stable isotope labeling and mass spectrometry. (2007) Mol. Cell Proteomics. 6(10):1771-7. DOI: 10.1074/mcp.M700057-MCP200

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Wan, Y., Saghatelian, A., Chong, L.W., Zhang, C.L., Cravatt, B.F., Evans, R.M. Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk. (2007) Genes & Development. 21(15):1895-908. DOI: 10.1101/gad.1567207

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Ostash, B., Saghatelian, A., Walker, S. A streamlined metabolic pathway for the biosynthesis of moenomycin A. (2007) Chemistry & Biology. 14(3):257-67. DOI: 10.1016/j.chembiol.2007.01.008

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Chiang, K.P., Niessen, S., Saghatelian, A., Cravatt, B.F. An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. (2006) Chemistry & Biology. 13(10):1041-50. DOI: 10.1016/j.chembiol.2006.08.008

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Saghatelian, A., McKinney, M.K., Bandell, M., Patapoutian, A., Cravatt, B.F. A FAAH-regulated class of N-acyl taurines that activates TRP ion channels. (2006) Biochemistry. 45(30):9007-15. DOI: 10.1021/bi0608008

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Leung, D., Saghatelian, A., Simon, G.M., Cravatt, B.F. Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids. (2006) Biochemistry. 45(15):4720-6. DOI: 10.1021/bi060163l

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Evans, M.J., Saghatelian, A., Sorensen, E.J., Cravatt, B.F. Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling. (2005) Nature Biotechnology. 23(10):1303-7. DOI: 10.1038/nbt1149

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Saghatelian, A., Cravatt, B.F. Assignment of protein function in the postgenomic era. (2005) Nature Chemical Biology. 1(3):130-42. DOI: 10.1038/nchembio0805-130

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Saghatelian, A., Cravatt, B.F. Discovery metabolite profiling–forging functional connections between the proteome and metabolome. (2005) Life Sciences. 77(14):1759-66. DOI: 10.1016/j.lfs.2005.05.019

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Go, E.P., Apon, J.V., Luo, G., Saghatelian, A., Daniels, R.H., Sahi, V., Dubrow, R., Cravatt, B.F., Vertes, A., Siuzdak, G. Desorption/ionization on silicon nanowires. (2005) Analytical Chemistry. 77(6):1641-6. DOI: 10.1021/ac048460o

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Saghatelian, A., Cravatt, B.F. Global strategies to integrate the proteome and metabolome. (2005) Current Opinion in Chemical Biology. 9(1):62-8. DOI: 10.1016/j.cbpa.2004.12.004

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Saghatelian, A., Trauger, S.A., Want, E.J., Hawkins, E.G., Siuzdak, G., Cravatt, B.F. Assignment of endogenous substrates to enzymes by global metabolite profiling. (2004) Biochemistry. 43(45):14332-9. DOI: 10.1021/bi0480335

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Lichtman, A.H., Leung, D., Shelton, C.C., Saghatelian, A., Hardouin, C., Boger, D.L., Cravatt, B.F. Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity. (2004) J. Pharmacol. Exp. Ther. 311(2):441-8. DOI: 10.1124/jpet.104.069401

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Cravatt, B.F., Saghatelian, A., Hawkins, E.G., Clement, A.B., Bracey, M.H., Lichtman, A.H. Functional disassociation of the central and peripheral fatty acid amide signaling systems. (2004) Proceedings of the National Academy of Sciences of the United States of America. 101(29):10821-6. DOI: 10.1073/pnas.0401292101

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Saghatelian, A., Jessani, N., Joseph, A., Humphrey, M., Cravatt, B.F. Activity-based probes for the proteomic profiling of metalloproteases. (2004) Proceedings of the National Academy of Sciences of the United States of America. 101(27):10000-5. DOI: 10.1073/pnas.0402784101

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Sánchez-Quesada, J., Saghatelian, A., Cheley, S., Bayley, H., Ghadiri, M.R. Single DNA rotaxanes of a transmembrane pore protein. (2004) Angew. Chem. Int. Ed. Engl. 43(23):3063-7. DOI: 10.1002/anie.200453907


Saghatelian, A., Völcker, N.H., Guckian, K.M., Lin, V.S., Ghadiri, M.R. DNA-based photonic logic gates: AND, NAND, and INHIBIT. (2003) Journal of the American Chemical Society. 125(2):346-7. DOI: 10.1021/ja029009m

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Saghatelian, A., Guckian, K.M., Thayer, D.A., Ghadiri, M.R. DNA detection and signal amplification via an engineered allosteric enzyme. (2003) Journal of the American Chemical Society. 125(2):344-5. DOI: 10.1021/ja027885u

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Merlic, C.A., Aldrich, C.C., Albaneze-Walker, J., Saghatelian, A., Mammen, J. Total synthesis of the calphostins: application of fischer carbene complexes and thermodynamic control of atropisomers. (2001) Journal of Organic Chemistry. 66(4):1297-309.

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Saghatelian, A., Yokobayashi, Y., Soltani, K., Ghadiri, M.R. A chiroselective peptide replicator. (2001) Nature. 409(6822):797-801. DOI: 10.1038/35057238

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Merlic, C.A., Aldrich, C.C., Albaneze-Walker, J., Saghatelian, A. Carbene Complexes in the Synthesis of Complex Natural Products: Total Synthesis of the Calphostins. (2000) Journal of the American Chemical Society. 122(13):3224-3225.