Nazarian, A., Lawlor, K., Yi, S. S., Philip, J., Ghosh, M., Yaneva, M., Villanueva, J., Saghatelian, A., Assel, M., Vickers, A. J., Eastham, J. A., Scher, H. I., Carver, B. S., Lilja, H. & Tempst, P. Inhibition of Circulating Dipeptidyl Peptidase 4 Activity in Patients with Metastatic Prostate Cancer. Molecular & cellular proteomics : MCP, (2014).

Oliver, P. M., Crooks, J. A., Leidl, M., Yoon, E. J., Saghatelian, A. & Weibel, D. B. Localization of anionic phospholipids in Escherichia coli cells. Journal of bacteriology, (2014).

Maianti, J. P., McFedries, A., Foda, Z. H., Kleiner, R. E., Du, X. Q., Leissring, M. A., Tang, W. J., Charron, M. J., Seeliger, M. A., Saghatelian, A. & Liu, D. R. Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature 511, 94-98, (2014).

Chin, R. M., Fu, X., Pai, M. Y., Vergnes, L., Hwang, H., Deng, G., Diep, S., Lomenick, B., Meli, V. S., Monsalve, G. C., Hu, E., Whelan, S. A., Wang, J. X., Jung, G., Solis, G. M., Fazlollahi, F., Kaweeteerawat, C., Quach, A., Nili, M., Krall, A. S., Godwin, H. A., Chang, H. R., Faull, K. F., Guo, F., Jiang, M., Trauger, S. A., Saghatelian, A., Braas, D., Christofk, H. R., Clarke, C. F., Teitell, M. A., Petrascheck, M., Reue, K., Jung, M. E., Frand, A. R. & Huang, J. The metabolite alpha-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature 510, 397-401, (2014).

Slavoff, S. A., Heo, J., Budnik, B. A., Hanakahi, L. A. & Saghatelian, A. A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining. The Journal of biological chemistry 289, 10950-10957, (2014). PMCID: PMC4036235.

Lone, A. M., Leidl, M., McFedries, A. K., Horner, J. W., Creemers, J. & Saghatelian, A. Deletion of PREPl causes growth impairment and hypotonia in mice. PloS one 9, e89160, (2014). PMCID: PMC3938459.

Ma, J., Ward, C. C., Jungreis, I., Slavoff, S. A., Schwaid, A. G., Neveu, J., Budnik, B. A., Kellis, M. & Saghatelian, A. Discovery of human sORF-encoded polypeptides (SEPs) in cell lines and tissue. Journal of proteome research 13, 1757-1765, (2014). PMCID: PMC3993966.

Pauli, A., Norris, M. L., Valen, E., Chew, G. L., Gagnon, J. A., Zimmerman, S., Mitchell, A., Ma, J., Dubrulle, J., Reyon, D., Tsai, S. Q., Joung, J. K., Saghatelian, A. & Schier, A. F. Toddler: an embryonic signal that promotes cell movement via Apelin receptors. Science 343, 1248636, (2014). PMCID: PMC4107353.

Liu, S., Brown, J. D., Stanya, K. J., Homan, E., Leidl, M., Inouye, K., Bhargava, P., Gangl, M. R., Dai, L., Hatano, B., Hotamisligil, G. S., Saghatelian, A., Plutzky, J. & Lee, C. H. A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use. Nature 502, 550-554, (2013).

Schwaid, A. G., Shannon, D. A., Ma, J., Slavoff, S. A., Levin, J. Z., Weerapana, E. & Saghatelian, A. Chemoproteomic discovery of cysteine-containing human short open reading frames. Journal of the American Chemical Society 135, 16750-16753, (2013). PMCID: PMC3868496.

Lopez-Sagaseta, J., Dulberger, C. L., McFedries, A., Cushman, M., Saghatelian, A. & Adams, E. J. MAIT recognition of a stimulatory bacterial antigen bound to MR1. Journal of immunology 191, 5268-5277, (2013). PMCID: PMC3819123.

Kim, Y. G., Lone, A. M. & Saghatelian, A. Analysis of the proteolysis of bioactive peptides using a peptidomics approach. Nature protocols 8, 1730-1742, (2013).

Mitchell, A. J., Lone, A. M., Tinoco, A. D. & Saghatelian, A. Proteolysis controls endogenous substance P levels. PloS one 8, e68638, (2013). PMCID: PMC3716696.

Tatematsu, S., Francis, S. A., Natarajan, P., Rader, D. J., Saghatelian, A., Brown, J. D., Michel, T. & Plutzky, J. Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium. Arteriosclerosis, thrombosis, and vascular biology 33, 1788-1794, (2013). PMCID: PMC3794714.

McFedries, A., Schwaid, A. & Saghatelian, A. Methods for the elucidation of protein-small molecule interactions. Chemistry & biology 20, 667-673, (2013).

Miraldi, E. R., Sharfi, H., Friedline, R. H., Johnson, H., Zhang, T., Lau, K. S., Ko, H. J., Curran, T. G., Haigis, K. M., Yaffe, M. B., Bonneau, R., Lauffenburger, D. A., Kahn, B. B., Kim, J. K., Neel, B. G., Saghatelian, A. & White, F. M. Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice. Integrative biology : quantitative biosciences from nano to macro 5, 940-963, (2013). PMCID: PMC3759823.

Lopez-Sagaseta, J., Dulberger, C. L., Crooks, J. E., Parks, C. D., Luoma, A. M., McFedries, A., Van Rhijn, I., Saghatelian, A. & Adams, E. J. The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins. Proceedings of the National Academy of Sciences of the United States of America 110, E1771-1778, (2013). PMCID: PMC3651419.

Zhang, T. & Saghatelian, A. Emerging roles of lipids in BCL-2 family-regulated apoptosis. Biochimica et biophysica acta 1831, 1542-1554, (2013).

Lone, A. M., Kim, Y. G. & Saghatelian, A. Peptidomics methods for the identification of peptidase-substrate interactions. Current opinion in chemical biology 17, 83-89, (2013). PMCID: PMC3594040.

Cezairliyan, B., Vinayavekhin, N., Grenfell-Lee, D., Yuen, G. J., Saghatelian, A. & Ausubel, F. M. Identification of Pseudomonas aeruginosa phenazines that kill Caenorhabditis elegans. PLoS pathogens 9, e1003101, (2013). PMCID: PMC3536714.

Slavoff, S. A., Mitchell, A. J., Schwaid, A. G., Cabili, M. N., Ma, J., Levin, J. Z., Karger, A. D., Budnik, B. A., Rinn, J. L. & Saghatelian, A. Peptidomic discovery of short open reading frame-encoded peptides in human cells. Nature chemical biology 9, 59-64, (2013). PMCID: PMC3625679.

Slavoff, S. A. & Saghatelian, A. Discovering ligand-receptor interactions. Nature biotechnology 30, 959-961, (2012).

Du, Y., Yang, M., Wei, W., Huynh, H. D., Herz, J., Saghatelian, A. & Wan, Y. Macrophage VLDL receptor promotes PAFAH secretion in mother’s milk and suppresses systemic inflammation in nursing neonates. Nature communications 3, 1008, (2012). PMCID: PMC3520613.

Du, Y., Yang, M., Lee, S., Behrendt, C. L., Hooper, L. V., Saghatelian, A. & Wan, Y. Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity. Genes & development 26, 1306-1311, (2012). PMCID: PMC3387658.

Kim, Y. G., Lone, A. M., Nolte, W. M. & Saghatelian, A. Peptidomics approach to elucidate the proteolytic regulation of bioactive peptides. Proceedings of the National Academy of Sciences of the United States of America 109, 8523-8527, (2012). PMCID: PMC3365226.

Tinoco, A. D., Thomas, H. R., Incarvito, C. D., Saghatelian, A. & Valentine, A. M. Cytotoxicity of a Ti(IV) compound is independent of serum proteins. Proceedings of the National Academy of Sciences of the United States of America 109, 5016-5021, (2012). PMCID: PMC3323991.

Guzman-Rojas, L., Rangel, R., Salameh, A., Edwards, J. K., Dondossola, E., Kim, Y. G., Saghatelian, A., Giordano, R. J., Kolonin, M. G., Staquicini, F. I., Koivunen, E., Sidman, R. L., Arap, W. & Pasqualini, R. Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment. Proceedings of the National Academy of Sciences of the United States of America 109, 1637-1642, (2012). PMCID: PMC3277167.

Kim, Y. G. & Saghatelian, A. Functional analysis of protein targets by metabolomic approaches. Topics in current chemistry 324, 137-162, (2012).

Vinayavekhin, N. & Saghatelian, A. Discovery of a protein-metabolite interaction between unsaturated fatty acids and the nuclear receptor Nur77 using a metabolomics approach. Journal of the American Chemical Society 133, 17168-17171, (2011).

Tinoco, A. D. & Saghatelian, A. Investigating endogenous peptides and peptidases using peptidomics. Biochemistry 50, 7447-7461, (2011). PMCID: PMC3418817.

Brown, J. D., Oligino, E., Rader, D. J., Saghatelian, A. & Plutzky, J. VLDL hydrolysis by hepatic lipase regulates PPARdelta transcriptional responses. PloS one 6, e21209, (2011). PMCID: PMC3130023.

Lone, A. M., Bachovchin, D. A., Westwood, D. B., Speers, A. E., Spicer, T. P., Fernandez-Vega, V., Chase, P., Hodder, P. S., Rosen, H., Cravatt, B. F. & Saghatelian, A. A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors. Journal of the American Chemical Society 133, 11665-11674, (2011). PMCID: PMC3145007.

Homan, E. A., Kim, Y. G., Cardia, J. P. & Saghatelian, A. Monoalkylglycerol ether lipids promote adipogenesis. Journal of the American Chemical Society 133, 5178-5181, (2011).

Tinoco, A. D., Kim, Y. G., Tagore, D. M., Wiwczar, J., Lane, W. S., Danial, N. N. & Saghatelian, A. A peptidomics strategy to elucidate the proteolytic pathways that inactivate peptide hormones. Biochemistry 50, 2213-2222, (2011). PMCID: PMC3076939.

Kim, Y. G., Lou, A. C. & Saghatelian, A. A metabolomics strategy for detecting protein-metabolite interactions to identify natural nuclear receptor ligands. Molecular bioSystems 7, 1046-1049, (2011).

Scharf, L., Li, N. S., Hawk, A. J., Garzon, D., Zhang, T., Fox, L. M., Kazen, A. R., Shah, S., Haddadian, E. J., Gumperz, J. E., Saghatelian, A., Faraldo-Gomez, J. D., Meredith, S. C., Piccirilli, J. A. & Adams, E. J. The 2.5 A structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation. Immunity 33, 853-862, (2010). PMCID: PMC3010391.

Lone, A. M., Nolte, W. M., Tinoco, A. D. & Saghatelian, A. Peptidomics of the prolyl peptidases. The AAPS journal 12, 483-491, (2010). PMCID: PMC2976987.

Vinayavekhin, N. & Saghatelian, A. Untargeted metabolomics. Current protocols in molecular biology / edited by Frederick M. Ausubel … [et al.] Chapter 30, Unit 30 31 31-24, (2010).

Tinoco, A. D., Tagore, D. M. & Saghatelian, A. Expanding the dipeptidyl peptidase 4-regulated peptidome via an optimized peptidomics platform. Journal of the American Chemical Society 132, 3819-3830, (2010). PMCID: PMC2842575.

Vinayavekhin, N., Homan, E. A. & Saghatelian, A. Exploring disease through metabolomics. ACS chemical biology 5, 91-103, (2010).

Nolte, W. M., Tagore, D. M., Lane, W. S. & Saghatelian, A. Peptidomics of prolyl endopeptidase in the central nervous system. Biochemistry 48, 11971-11981, (2009). PMCID: PMC2813186.

MacBeath, G. & Saghatelian, A. The promise and challenge of ‘-omic’ approaches. Current opinion in chemical biology 13, 501-502, (2009).

Vinayavekhin, N. & Saghatelian, A. Regulation of alkyl-dihydrothiazole-carboxylates (ATCs) by iron and the pyochelin gene cluster in Pseudomonas aeruginosa. ACS chemical biology 4, 617-623, (2009).

Rodgers, M. A., Saghatelian, A. & Yang, P. L. Identification of an overabundant cholesterol precursor in hepatitis B virus replicating cells by untargeted lipid metabolite profiling. Journal of the American Chemical Society 131, 5030-5031, (2009).

Tagore, D. M., Nolte, W. M., Neveu, J. M., Rangel, R., Guzman-Rojas, L., Pasqualini, R., Arap, W., Lane, W. S. & Saghatelian, A. Peptidase substrates via global peptide profiling. Nature chemical biology 5, 23-25, (2009). PMCID: PMC2730040.

Tagore, R., Thomas, H. R., Homan, E. A., Munawar, A. & Saghatelian, A. A global metabolite profiling approach to identify protein-metabolite interactions. Journal of the American Chemical Society130, 14111-14113, (2008).